ames test การใช้

• The Ames test found no evidence of any potential mutagenic or toxicity properties.
• The antimutagenic properties of whole, fresh-water AFA were tested using the Ames test.
• It also has mutagenic activity, as measured by the Ames test.
• MeIQ, IQ and 8-MeIQx are the most potent mutagens according to the Ames test.
• BPF was not found to produce any genetic mutation when tested via an Ames test.
• Thirdly, it can prove an effective method to discriminate false positive results in the Ames test.
• Long toxicology and outcome studies are needed with such compounds to disprove a positive Ames test.
• Furthermore, the metabolic enzymes of bacteria used in the Ames test differ substantially from those in mammals.
• Myricetin also has been shown to inhibit the act of genetic mutation as exhibited by the Ames test.
• He is the inventor of the Ames test, a system for easily and cheaply testing the mutagenicity of compounds.
• It serves as a useful and cost effective complement to the traditional Ames test for a number of reasons.
• The S9 fraction has been used in conjunction with the Ames test to assess the mutagenic potential of chemical compounds.
• The same high concentration of ShK-170 was negative in the Ames test on tester strain TA97A, suggesting that it is not a mutagen.
• Therefore, to mimic the metabolism of test substance that would occur in mammals, the S9 fraction is often added to the Ames test.
• Agaritine has been shown to test positive as a mutagen in the ames test and mutagenize DNA in the bacterium " Salmonella typhimurium ".
• Mutagens identified in the Ames test need not necessarily be carcinogenic, and further tests are required for any potential carcinogen identified in the test.
• Secondly, it may allow the detection of genotoxic chemicals which yield false negatives in the Ames test ( such as estradiol, a compound of growing concern ).
• By the 1970s, the " Ames test " was the world's most widely used method for identifying potential carcinogens in everything from clothing to hair dye to pharmaceuticals.
• In Ames test, where the varying concentrations of the chemical are used in the test, the dose response curve obtained is nearly always linear, suggesting that there is no threshold for mutagenesis.
• A large number of chemical mutagens have since been identified, especially after the development of the Ames test in the 1970s by Bruce Ames that screens for mutagens and allows for preliminary identification of carcinogens.